Welcome to the Collaborative Research Center 815

Since January 2009 the DFG is funding the Collaborative Research Center 815 “Redox-Regulation” at the Goethe-University Frankfurt. After the successful second reapplication we are within third and last funding period, starting January 2017. End of the funding period will be December, 2020.

Redox-regulated processes are positioned at the interface between genome coded structure/function relationships and their adaptation to the availability of oxygen, the generation of superoxide, nitric oxide, and hydrogen sulfide as well as their metabolites. It can be seen as a fundamental control mechanism like phosphorylation/ dephosphorylation in regulating and coordinating cellular functions.

During the first funding period we focused on “Activation of Generating Systems”, i.e. NADPH-oxidases, respiratory chain complexes, prolyl hydroxylases, and cystatione γ-lyases. In the second funding period key aspects comprised “Investigations towards distinct effector structures” and functional consequences affecting inflammation, mitochondrial respiration, and the control of individual signaling complexes. The aim of the third funding period is to consolidate our knowledge of generating system and the epiproteome to further advance our understanding of the “Redox imprinting of biological systems”.

At an interdisciplinary level the CRC aims at contributing and understanding the imprinting of cardiovascular, oncological/immunological, and neurological systems by identifying and modulating redox-signatures. A detailed knowledge and an appreciation on general concepts towards redox-networks should enable others to use our findings and apply them to future question in biomedicine.

Speaker

Prof. Dr. rer. nat. Bernhard BrĂĽne

Goethe University I Faculty of Medicine
Institute of Biochemistry 1 I Haus 74
Theodor-Stern-Kai 7 I 60590 Frankfurt


Phone: 069-6301-7424
Fax: 069-6301-4203
Email:

Co-Speaker

Prof. Dr. med. Ralf Brandes

Goethe University I Faculty of Medicine
Institute of Cardiovascular Physiology I
Haus 75
Theodor-Stern-Kai 7 I 60590 Frankfurt

Phone: 069-6301-6049
Fax: 069-6301-7668
Email:

Coordination

Dr. phil. nat. Manuela Diehl

Goethe University I Faculty of Medicine
Institute of Biochemistry 1 I Haus 74
Theodor-Stern-Kai 7 I 60590 Frankfurt


Phone: 069-6301-4928
Fax: 069-6301-4203
Email: