Project 01

 

Nox4 as a redox switch in epigenetics and metabolism



Principal Investigator:

Prof. Dr. Katrin Schröder
Institute of Cardiovascular Physiology
Goethe University Frankfurt/Main
  Prof. Dr. Ralf Brandes
Institute of Cardiovascular Physiology
Goethe University Frankfurt/Main

Research Area:

Vascular Research, Inflammation, Molecular Biology

Summary:

The NADPH oxidase Nox4 mediates cellular differentiation, maintains endothelial quiescence and regulates angiogenesis by controlling the expression of Hif1α. In the new funding period we will focus on the following key aspects: 1. Identification the role of Nox4 in differentiation from iPSCs into endothelial cells. 2. Identification of Nox4s role in Hif1α expression and 3. Analysis of the role of Nox4 in metabolomics control.

Links:

Institute for Cardiovascular Physiology (http://www.vrc.uni-frankfurt.de)