Project 10

Dissecting the ROS-regulatory mechanisms of Sestrin 2-dependent mTORC1 suppression

 


Principal Investigator:

Dr. Nina Kurrle
Medical Clinic II: Hematology and Oncology
Goethe University Frankfurt/Main
  Prof. Dr. Hubert Serve
Medical Clinic II: Hematology and Oncology
Goethe University Frankfurt/Main

Research Area:

Hematology, Oncology, Genetics, Functional Genomics

Summary:

Sestrin 2 (Sesn2) is a cellular stress protein, which recently was described to function as an amino acid sensor to regulate mTORC1 activity in cooperation with the GATOR complex. In preliminiary work, we could show that Sesn2/GATOR additionally functions as a ROS-sensitive suppressor of mTORC1 signaling and modulates hematopoietic stem cell function. Therefore, we will unravel Sesn2-dependent mechanisms coupling cellular redox homeostasis, metabolism of amino acids and putative (patho-)physiological impacts on hematopoietic stem cell function and leukemia development.

Links:

Medical Clinic II (http://www.kgu.de/index.php?id=48&L=0)