Project 10
Dissecting the role of sestrins and peroxiredoxins in hematopoietic growth factor signaling and myeloid leukemogenesis
Principal Investigator:
Prof. Dr. Hubert ServeProf. Dr. Harald von Melchner
Medical Clinic II: Hematology and Oncology
Goethe University Frankfurt/Main
Research Area:
Hematology, Oncology, Genetics, Functional GenomicsSummary:
By using a combination experimental hematology, genetic and proteomic approaches, this project seeks to characterize the role of sestrins (sesn2) and peroxiredoxins (Prx I and II) in the regulation of Flt3 and c-kit receptor tyrosine kinase (RTK) signaling in normal and leukemic hematopoiesis. Moreover, this project will examine the putative tumor suppressor function of sens2 in dedicated leukemogenicity assays performed with different strains of sesn2 knockout mice.