Project 12

 

Nucleoredoxin as regulator of neuronal activity and plasticity



Principal Investigator:

Prof. Dr. Irmgard Tegeder
Institute of Clinical Pharmacology
Goethe University Frankfurt/Main

Research Area:

Pharmacology, Pain and Inflammation

Summary:

The aim of the project is to characterize functions of nucleoredoxin (Nxn) for neuronal redox-homeostasis in health, aging, stress response and after axonal injury. These questions shall be addressed in vitro and in vivo using neuron-specific Nxn-deficient mice. We will analyze the behavior using models of neuropathic pain, learning & memory and chronic unpredictable mild stress. The plasticity of dendritic spines and calcium signals shall be analyzed in brain slice cultures and primary cells and we will employ proteomic studies to characterize Nxn-dependent redox-signatures and the Nxn-interactome.

Links:

Institute of Clinical Pharmacology (http://www.kgu.de/zpharm/klin/)