Project 13

 

Mechanisms and consequences of a defect redox control of Kv4.3 channels in Morbus Parkinson



Principal Investigator:

Prof. Dr. Jochen Roeper
Institute of Neurophysiology
Goethe University Frankfurt/Main

Research Area:

Neurophysiology

Summary:

We aim to clarify the mechanisms that lead to an altered redox-state of Kv4.3 potassium channels and in turn to hyperactivity in dopamine substantia nigra (DA SN) neurons in a transgenic mutant alpha-synuclein mouse model of Parkinson disease (PD). By comparison with a CRISP/Cas-mediated redox-insensitive Kv4.3 mutant (C110), we aim to define the causal role of redox-mediated hyperactivity for selective neurodegeneration of DA SN neurons in PD.

Links:

Institute of Neurophysiology (http://www.physiologie.uni-frankfurt.de/Indoor/Zphys2/) )