Project 16

 

Functional consequences of a redox regulated activation of calpain in diabetes



Principal Investigator:

Prof. Dr. Ingrid Fleming
Institute for Vascular Signalling
Goethe University Frankfurt/Main

Research Area:

Cardiovascular Physiology, Vascular Biology

Summary:

The project focuses on the calpain family of Ca2+-activated proteases and their endogenous inhibitor protein calpastatin (CAST) as well as on the role of the calpain/CAST proteins in processes usually attributed to redox signalling. Particular attention will be paid to regulation by microRNA and the consequences of calpain activation/inactivation on the mitochondrial proteome and function, including alterations in a-ketoglutarate levels and the activity of members of the Jumonji C domain-containing histone lysine demethylase (Jmj-KDM) family.

Links:

Institut für Vaskular Signalling (http://www.ivs.uni-frankfurt.de/)