Project 17

 

Mechanism and functional consequences of the Toll-like receptor 2-mediated alteration of the mitochondrial ROS production



Principal Investigator:

Dr. Jan Mersmann
Clinic for Anesthesiology,
Intensive Care, and Pain Therapy
Goethe University Frankfurt/Main
  Prof. Dr. Dr. Kai Zacharowski
Clinic for Anesthesiology,
Intensive Care, and Pain Therapy
Goethe University Frankfurt/Main

Research Area:

Anesthesiology, Intensive care, Experimental Cardiology, Pharmacology

Summary:

Within the first SFB-period we identified a TLR2-dependent modulation of ROS production within the respiratory chain. TLR2-/--heart mitochondria displayed reduced - putatively adverse - complex I derived ROS, while - putatively protective - ROS-production via complex III was increased. The objective of the new project is the identification of the intracellular signalling pathway between TLR2 and the respiratory chain. We furthermore aim to investigate the relevance of the observed changes in redox-state of several proteins for their function during myocardial ischemia and reperfusion.

Links:

Clinic for Anesthesiology, Intensive Care, and Pain Therapy (http://www.kgu.de/index.php?id=976&L=0)