This project investigates the redox-dependent regulation of toll-like receptor 2 (TLR2) during myocardial ischemia and reperfusion and its functional consequences on myocardial wound healing, remodeling, dysrhythmias, and heart failure. Using different mouse models and in vitro studies on isolated cardiomyocytes the objective is to (i) identify endogenous ligands of TLR2, (ii) elucidate the intracellular signal transduction, and (iii) describe the redox-dependent regulation of intercellular connexin43 gap junctions in the setting of myocardial ischemia and reperfusion. The aim is to identify targets for interception with TLR2- and redox signaling to develop new therapeutic strategies against myocardial reperfusion injury.

Links:

Clinic for Anesthesiology, Intensive Care, and Pain Therapy (http://www.kgu.de/index.php?id=976&L=0)