Project 02


Control Mechanisms of mitochondrial ROS-production during cellular redox signaling


Principal Investigator:

Dr. Stefan Dröse
Clinic for Anesthesiology, Intensive Care and Pain Therapy
Goethe University Frankfurt/Main

Research Area:

Biochemistry, Molecular and Cellular Bioenergetics

Summary:

Due to their inventory of superoxid-generators and antioxidative proteins mitochondria take center stage in the control of cellular signal transduction processes regulated by redox changes. The central goal of our project is to validate the generator-specific redox-markers identified in the first funding period in an ischemia/reperfusion mouse-model and to analyze the functional consequences of the redox-modifications involved. Moreover, we will investigate the impact of antioxidative proteins like the peroxiredoxins on mitochondrial signal transduction.

Links:

Clinic for Anesthesiology, Intensive Care and Pain Therapy
(http://www.kgu.de/fachkliniken/zaw/anaesthesiologie-intensivmedizin-und-schmerztherapie/forschung-in-kais.html)