Macrophage polarization in response to contact to apoptotic cells is characterized by an anti-inflammatory expression profile and an active suppression of the pro-inflammatory cytokine response. Mechanisms provoking inhibition of NADPH oxidase activity as a marker of macrophage polarization so far remain unclear. Therefore, we will identify and characterize mechanisms leading to NADPH oxidase inhibition. Moreover, the role of NADPH oxidase inhibition during the pathophysiological conditions during sepsis will be clarified to use it as a possible starting-point for a potential therapy.

Links:

Institute of Biochemistry I (http://www.pathobiochemie1.de/)