Project 05

 

Crosstalk between matrix and ROS signaling during renal inflammation and fibrosis



Principal Investigator:

Prof. Liliana Schaefer
Institute of General Pharmacology and Toxicology
Goethe University Frankfurt/Main

Research Area:

Pharmacology, Nephropharmacology

Summary:

In the last funding period we have demonstrated that soluble biglycan, an endogenous ligand of the innate immune receptors TLR2/4, evokes albuminuria in a ROS-dependent mannner and modulates the progression of inflammatory renal diseases via NOX2. Our main goal is to decipher the cellular mechanism of biglycan-mediated modulation of the redox-homeostasis for the development of novel anti-proteinuric and anti-inflammatory therapies. Accordingly, in this project we will identify the source and determine the impact of ROS on biglycan-induced albuminuria, and will mechanistically investigate biglycan-dependent stabilization of NOX2 for the inhibition of IL-1β synthesis.

Links:

Institute of General Pharmacology and Toxicology (http://www.kgu.de/zpharm/allg/)