Project 07

 

Hydrogen sulfide (H2S) as a regulator of redox homeostasis during glomerulonephritis



Principal Investigator:

Prof. Dr. Josef Pfeilschifter
Institute of General Pharmacology and Toxicology
Goethe University Frankfurt/Main

Research Area:

Pharmacology, Immunepharmacology

Summary:

Various forms of inflammatory diseases are accompanied by a massive synthesis of redox-active mediators such as ROS, NO and H2S. We developed a method that allows the proteom-wide detection of hydropersulfides on cysteines as H2S-induced redox switches. The aim of this research project is to demonstrate the relevance of these thiol-based redox switches for glomerular nephropathies and cutaneous wound healing in suitable cell culture and animal models. The detailed knowledge of redox-modifications of cysteine residues as a concerted target of ROS, NO and H2S should help to elaborate therapeutic strategies for the treatment of inflammatory diseases.

Links:

Institute of General Pharmacology and Toxicology (http://www.kgu.de/zpharm/allg/)