Project 9

 

Metabolic Syndrome: reactive oxygen species-mediated proinflammatory signaling via the ER in macrophages during impaired wound healing



Principal Investigator:

Prof Dr. Stefan Frank
Institute of General Pharmacology and Toxicology
Goethe University Frankfurt / Main

Research Area:

Molecular Medicine, Pharmacology, Dermatology

Summary:

Obesity represents a chronic inflammatory disease, which functionally determines a pro-inflammatory macrophage (Mφ) phenotype within the affected organism. Adipose tissue-activated Mφ cause severe wound healing disorders in obese mice. Our project investigates endoplasmic reticulum-mediated functional roles of reactive oxygen species (ROS) in the activation of pro-inflammatory signaling pathways in Mφ, as this organelle enables the integration of metabolic conditions and pathways of innate immunity.

Links:

Institute of General Pharmacology and Toxicology (http://www.kgu.de/zpharm/allg/)