Central Project 1

 

Redox-Proteomics



Principal Investigator:

Prof. Dr. Ulrich Brandt
Prof. Dr. Hermann Schägger
Molecular Bioenergetics
Goethe University Frankfurt/Main

Research Area:

Protein Chemistry, Electrophoresis, Mass Spectrometry

Summary:

Project Z1 helps to identify proteins and redox-dependent protein modifications using gel electrophoretic and mass spectometric analysis techniques. The spectrum of objects analyzed in 11 subprojects of the SFB ranges from specific model proteins exposed to reactive oxygen species to the analysis of proteomic changes of whole cells. Correlating physiological state and protein modification, the mechanisms of redox signaling can be elucidated on a molecular level. The identification of novel redox-dependent protein modifications permits insight into the mechanisms of redox signaling.

Links:

Molekulare Bioenergetik (http://www.zbc.kgu.de/Bioenergetik/)