Project 21

 

Molecular mechanisms of the redox regulation of necroptosis during acute lymphatic leukemia



Principal Investigator:

Prof. Dr. Simone Fulda
Institute for Experimental Cancer Research in Pediatrics
Goethe University Frankfurt/Main

Research Area:

Pediatrics, Molecular Oncology

Summary:

The project aims at identifying the molecular mechanisms of redox signaling as regulatory principle of signal transduction during necroptosis as alternative mode of programmed cell death in preclinical in vitro and in vivo models of apoptosis-resistant leukemia. The results of the project are expected to open new perspectives for targeted therapeutic interventions in necroptosis signaling and have important implications for various fields of life sciences where defects in cell death programs occur.

Links:

Institute for Experimental Cancer Research in Pediatrics (http://www.kinderkrebsforschung-frankfurt.de/institut/index.html)