Project 22


Role of the phospholipid hydroxyperoxide glutathion peroxidase (PHGPx) GPx4 in murine hepatozytes and hepatocarcinogenesis

Principal Investigator:

Prof. Dr. Florian Greten
Institute Tumor Biology and Experimental Therapy
Georg-Speyer-Haus, Frankfurt/Main

Research Area:

Biochemistry, Tumor Biology, Inflammation


Glutathion-Peroxidase 4 is part of the anti-oxidant system of the cell and a loss can trigger a specific form of cell death, namely ferroptosis. Aim of this new project is the investigation of role of GPx4 in the liver using hepatocyte specific GPx4 knockout mice. Another focus lies on investigating the GPx4-dependent ferroptosis in transposon based models of hepatocarcinogenesis and non-alcoholic steatoheapatitis (NASH) using suitable genetic mouse models.